Scientists in Edinburgh in Scotland are to carry out a study that Genetic Factor is to be important contributors to sperm count and male infertility. Genetic factors are behind the increasing infertility in men. In fact, even in men with no known fertility problems, 19% of the sperm are genetically defective. According to our previous research, suggested that diet, lifestyle, smoking or even dress may contribute to the increase of this problems which comes under in genetic disorder. Some important evidence proof that “due to genetic disorder, male reproductive function seems to have deteriorated considerably in the past four to five decades”.
The lower the sperm count, the more genetic defects were observed. Researches proof, there are around 43% of men have low sperm count and male infertility. Concerns have been raised that children conceived through IVF are at an increased risk of genetic imprinting disorders.
Abnormalities in genes that specifically regulate sperm production and quality are major factors in male infertility. Impact of adverse genetic environmental factors such as hormone disrupters, disruption in Sertoli Cell function, leads to reduced semen quality and testicular cancer.
Cause of Low Sperm Count
These are some Inherited Disorders that Affect Fertility:-
Wiedemann syndrome, which causes too much growth and is linked with an increased chance of tumors.
Angelman’s syndrome, which affects the development of the brain.
Cystic fibrosis, patients often has missing or obstructed vas deferens (the tubes that carry sperm) and hence a low sperm count.
Klinefelter syndrome patients carry two X and one Y chromosomes (the norm is one X and one Y), which leads to the destruction of the lining of the seminiferous tubules in the testicles during puberty, although most other male physical attributes are unimpaired.
Kartagener syndrome, a rare disorder that is associated with a reversed position of the major organs, also includes immotile cilia (hair-like cells in lungs and sinuses that have a structure similar to the tails of sperm). Germ cells may also be affected by this condition.
Polycystic kidney disease, a relatively common genetic disorder that causes large cysts to form on the kidneys and other organs during adulthood, may cause infertility as the first symptom if cysts develop in the reproductive tract.
Testicular dysgenesis syndrome (TDS), that it is likely to be caused by environmental factors as well as, genetic disorders. Their proposal is based on well-established understanding of the way in which the male reproductive tract develops, particularly the way that variation in fetal hormonal levels can lead to disease and dysfunction.
Professor Barratt said couples undergoing fertility treatment, can help to male fertility issue because the man had a low sperm count should be counseled about the risk of their child being affected by a genetic condition. “What the patient then does with that information is up to them. They have to decide whether to take the risk of not have a child.” Scientists could carry out tests on sperm to see if men were affected, than they give better solution according their problem so it may more helpful to them.